Bone Biology and Mechanics Lab: BBML

Welcome to the BBML in the Department of Biomedical Engineering at Indiana University-Purdue University at Indianapolis (IUPUI). The BBML is committed to improving our understanding of how the body works through innovative preclinical and clinical research. As our name implies, the lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass). We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy.

Bone Hierarchy

Our long-term goal is to use combinatorial treatments for a number of relevant diseases that have musculoskeletal complications which lead to bone fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations of bone quality and quantity to intervene and increase bone fracture resistance even in the face of inferior tissue quality. A common thread that passes through all of our research is an intense focus on collagen and the role it plays in bone health. Our research is currently funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Science Foundation (NSF), the US Department of Veteran Affairs (VA), the Indiana Clinical and Translational Sciences Institute (CTSI), and the IUPUI Office of the Vice Chancellor for Research. Grant details can be found here.

Lab Intro

Recent Lab News

2022 has started strong, and the lab has already been a part of several publications including 2 accepted in the Journal of Bone and Mineral Research (JBMR) in the same week! Please check out the publications section of the site for all the details. Congrats to all!

The lab welcomes Joseph Bustamante, a new PhD students starting this summer.

Congratulations to JD for successfully defending his PhD dissertation "Multiscale Characterization of Skeletal Properties in Diabetes and Chronic Kidney Disease."" He will be missed as he heads back to his 3rd year of Medical School in the Indiana University School of Medicine in March.

Continuing the turnover in the lab, we are sad to say goodbye to Claudia as she completed her postdoctoral work in the lab in December 2021. At the same time, the lab is happy to welcome a new postdoc, Andy Tomaschke, and a new undergraduate researcher, Shelby Busker.

The lab will be well represented at the 2022 Annual Meeting of the Orthopaedic Research Society in Tampa! We will have 4 poster presentations (Congrats to Amy, Claudia, Jen, and Nusaiba) and 2 podium presentations (Congrats to JD and Rachel S.) covering the work we continue in Osteogenesis Imperfecta, and some of our exciting new work in Diabetes and Chronic Kidney Disease. We are all looking forward to the first in-person conference the lab has attended as a group in 2 years.

Amy and Rachel S presented posters at the recent 2021 Annual Meeting of the American Society for Bone and Mineral Research. JD also had an oral presentation and earned a Young Investigator Award. Congrats everyone!

On August 1, 2021, the interim tag was removed and Professor Wallace took on the role of Chair of the Department of Biomedical Engineering at IUPUI.

Congratulations to Jen Hatch for successfully defending her MS thesis "Sex-Specific Bone Phenotype in the Streptozotocin-Induced Murine Model of Diabetes." Jen transitioned into the BME PhD research program in August and was awarded the Indiana University President Diversity Fellowship!

After 10 years in existence, the BBML has finally found a lab manager to help with the day to day operations of the lab. As of January 1, 2021, we welcome Dyann Segvich to the team!

Recent Research


A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.

BBML People

BBML People

Click below to learn more about the people in our lab who make all of this exciting work possible.

Recent Publication


Our lab actively publishes in journals spanning the areas of bone and mineral and general biomechanics. To view of list of our publications, click the link below.

Send us a message

Other ways to reach us